Biomechanics and Mechanobiology

Activities focus on the combined use of mechanical engineering principles and biological knowledge to understand disease progression and the performance of medical devices.

Central mechanical aspects are fluid dynamics, thermal transport, elastic and dynamics processes and materials in living systems.

APPLICATIONS / CHALLENGES / RESEARCH DIRECTIONS

  • To improve people's quality of life by provide improved understanding of disease progression or usage of medical devices. The challenges often arise from the complexity realised in biological settings.


MAIN SCIENTIFIC AND TECHNICAL INTERESTS

  • Development of scaffolds for tissue engineering and regenerative medicine with an emphasis on the production and characterisation of micro- and nanofunctionalised 3D scaffolds as advances bio active implant materials.
  • Within the concept of Computer Aided Biological Response Assessment (CABRA) to develop mathematical models of biological activities like disease progression, implant performance, or cellular motility. In particular, we have studied atherosclerosis and cancer.

Faculty

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Key publications

    Li, Y.-F. et al., 2015. Ultraporous Electrospun PCL-PEO Microfibrous Scaffolds Enhance Cell Infiltration and Colonization, Nanoscale, 2015

    Wittenborn, T.R. et al., 2014. Accumulation of nano-sized particles in a murine model of angiogenesis. Biochemical and Biophysical Research Communications, 443(2), pp.470–476.

    Andersen, M.Ø. et al., 2013. Spatially Controlled Delivery of siRNAs to Stem Cells in Implants Generated by Multi‐Component Additive Manufacturing. Advanced Functional Materials, 23, pp.5599–5607.

    Nygaard, J.V. et al., 2011. Characterisation of internal morphologies in electrospun fibers by X-ray tomographic microscopy. Nanoscale, 3(9), pp.3594–3597.

    Nygaard, J.V. et al., 2008. Investigation of particle‐functionalized tissue engineering scaffolds using X‐ray tomographic microscopy. Biotechnology and Bioengineering, 100(4), pp.820–829.